- Overview
- Objectives
- Research Projects
- Services
- Contact Details
The Medical Research Core Facility and Platforms serve the MNG-HA scientific community’s needs for reagents, assays, samples and data analysis for the conduct of research projects.
The Medical Research Core Facility and Platforms is comprised of the following units: Cell & Tissue Culture, Biochemical & Molecular Biology, Drug Discovery, Immunology, Light & Electron Microscopy and Mass Spectrometry and Medicinal Chemistry. Each unit has specific purpose and contribution to support the researchers.
To provide researchers with:
- Customized Research Reagents: Cell lines, Proteins etc.
- Services in Cell Culture, Proteomics & Metabolomics, Cell Imaging, Microscopy, Drug Screening, Medicinal Chemistry, Analytical Chemistry, Protein Expression etc.
- Laboratory space fully equipped with the latest research platforms
- Assist researchers in the conduct of their biomedical research in a safe environment.
- Drug Discovery
- Cancer Research
- Rare Diseases Research
- Cardiovascular Research
- Cell Culture Facility
- Primary and Cell lines Culture
- Stem Cell Differentiations
- Stable Cell line generation
- Transfection
- PBMC Isolation
- Biochemistry, Microbiology and Molecular Biology Lab
- Plasmid/DNA/RNA/Protein Extraction and their bioanalysis (western blot, gel electrophoresis)
- PCR, PC-RFLP, qPCR
- Recombinant protein Expression & Purification
- Lentivirus and Baculovirus Lab
- Lentivirus for shRNA expression for gene knock-down
- Lentivirus for gene overexpression
- Lentivirus for cell stable-labeling
- Bio-Imaging Suite
- Life Technologies EVOS FL system equipped with life cell imaging capability
- Molecular Devices Image Express High Content Imaging System
- Imaging using Image Express (Molecular Devices)
- Jeol JEM-1400 Transmission Electron Microscope (TEM)
- FEI Nova SEM Scanning Electron Microscope (SEM)
- Zeiss LSM 780 Laser Scanning Confocal Microscope (cLSM) with life cell imaging capability
- Nikon Total Internal Reflection Fluorescence Microscope system (TIRF)
- Zeiss Laser Capture Microdissection (LCM) system equipped with PALM Micro Tweezers and life cell imaging capability
- Immunology and Flow-Cytometry Platform
- Fluorescence-activated cell analysis and sorting
- BD FACS Canto II: Quantitative and qualitative analysis and characterization of cells, molecules and particles
- MoFlo XDP Cell Sorter: Cell Analysis and Isolation from human or animal model.
- Bio-Plex® 3D Suspension Array System: High-throughput testing for nucleic acid and protein applications
- Cell Culture: Services for culture of different cell lines available in Core Lab department
- Mass Spectrometry
- Discovery and Targeted Proteomics
- Discovery and Targeted Metabolomics
- Molecular weight determination
- Analysis of compounds for structural elucidation
- Impurity Analysis
- Drug Discovery, Medicinal & Analytical Chemistry
- Design and Synthesis of Biologically Active Compounds
- Optimization of Drug Candidates and SAR Development
- Purification and Identification of Small Molecule
- Antibody Drug Conjugates Preparation
- PET Tracer Design
- Consultancy on API Synthesis
- Assay Development
- Lentivirus based shRNA
- Plate readers: Fluorescence, FRET, Luminescence etc.
- Disease specific assay: Reporters, Colony Formation, Primary Cell Culture, Stable Cell line generations, etc.
- Antibody Generation – Coming Soon
- Email: Kaimrc-core@ngha.med.sa
- Extension: (84) 94481 / (84) 94480